Khyber Med Univ J ;6: It is now noted that for differentiated thyroid carcinoma DTC , there is a changing trend towards the frequent occurrence of PTC compared to FTC and this may be attributable to wide spread iodization programs Fine needle aspiration cytology of thyroid nodules at Kenyatta National Hospital, Nairobi. Please review our privacy policy. O Box Gulu – Uganda.

Fine-needle aspiration of the thyroid an overview. The Purposive convenient sampling technique was used to complete this study in two years i. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were Distribution of cases as per duration of swelling in years Click here to view. Size, number, and distribution of thyroid nodules and the risk of malignancy in radiation-exposed patients who underwent surgery.

Transcriptional and proteomic analysis reveal recombinant galectins of Haemonchus contortus down-regulated functions of goat PBMC and modulation of several signaling cascades in vitro. In some studies, Thyrlid has been found to have a low accuracy for malignancy.

The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer

The findings are consistent with findings of other studies 1617 who reported that size of nodule and interval of growth of nodule are not helpful for predicting or excluding thyroid malignancy. Paraffin embedded cellblocks were kept for Galectin-3immunostaining. Most of them presented with large goitres which were present since many years. The authors appreciate the co-operation of patients who participated in this study, the staff from the records section of Pathology Department for retrieving patients’ data and Dr.

The present study was conducted in a university- affiliated tertiary referral Hospital from September to February Evaluation of non-palpable thyroid nodules by tyyroid sound guided fine needle aspiration cytology. The minimum and maximum nodule size was two and cm three cms respectively.


thyroid fnac thesis

Social demographic characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm. Amongst these, the most frequent one was papillary carcinoma and it was followed by follicular adenoma. The use of a combination of galectin-3 and thyroid peroxidase for the diagnosis and prognosis of thyroid cancer. The sensitivity for diagnosing malignancy on FNAC was A benign FNAC diagnosis should be viewed with caution as false negative results do occur and these patients should be followed up and any clinical suspicion of malignancy even in the presence of benign FNAC requires surgery.

thyroid fnac thesis

A total of 99 patients were enrolled 45 prospective and 54 retrospective. Pak J Med Sci.

Immunohistochemical staining of the sections prepared from the cellblocks was done. Role of ultrasonography in the diagnosis and management of thyroid cancer. Galectin-3 and Ki expression in multiglandular parathyroid lesions. The results were quite thesus to the results of a study conducted by Herraiz et al.

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thyroid fnac thesis

Malignancy was noted in 13 RM developed the concept, participated in data collection and manuscript writing, PKO participated in data collection, analysis, manuscript writing, JOF and DW reviewed the concept, data analysis and manuscript. Our objective was to investigate the role of Galectin-3 in fine needle aspirates of thyroid nodules as a prospective diagnostic marker and consequently its ability to differentiate benign from malignant neoplasms.


After processing, tissue embedding was done using paraffin wax. Therefore, it can be complementary to other diagnostic techniques in patients with thyroid nodules; however, further exploration especially considering large number of patients with different thyroid nodules sizes is needed to validate its clinical role. The patient was made to lie supine on an examination couch with slight neck extension and a sand bag nfac the shoulders.

Journal of Thyroid Research

Combined 99 mTc-methoxyisobutylisonitrile scintigraphy and fine-needle aspiration cytology offers an accurate and potentially cost-effective investigative strategy for the assessment of solitary or dominant thyroid nodules. The distribution of parameters was fanc using probability plots and the Shapiro-Wilk test.

Despite several studies showing a high accuracy with FNAC, emerging studies especially in tropical Africa and other developing countries with a high prevalence of nodular thyroid disease, have shown the accuracy of FNAC to be lower than previously reported 4 — 5 and its diagnostic performance has been shown to vary across different studies 6.

The sensitivity and specificity for detecting malignancy on FNAC was To study the histopathological fnaac.

Diagnostic accuracy of fine needle aspiration cytology in thyroid nodules. Characteristics of the patients were shown in Table 1.